Swift Hybridization Capture Kits, enable enrichment and sequencing of the human exome or subsets of disease-related genes involved in cancer and inherited diseases. Our kits save sequencing costs by targeting only genes of interest using a 4-hour capture, while delivering the breadth and depth of coverage required for comprehensive yet sensitive genomic profiling.
The high quality of Swift panels, combined with optimized hybridization reagents and protocols, results in a substantial improvement in on-target mapping rate and coverage uniformity compared to other commercially available panels. The panels are designed to allow variants to be called using fewer reads, and therefore, at lower costs.
These products include gene-specific capture probes and supporting hybridization and wash reagents, including beads and blockers. When used in conjunction with Swift’s portfolio of library preparation kits including library adapters with molecular identifiers, labs have a variety of complete workflow options to convert input DNA into targeted Illumina®-compatible libraries in a 1.5-day workflow.
Enables enrichment of the human exome or subsets of disease-related genes
Superior on-target performance and comprehensive coverage of human coding sequences from the RefSeq database, probes designed to version hg19
Saves sequencing costs
Pre-capture multiplexing facilitates orders of magnitude more efficient next generation sequencing by targeting genes of interest while conserving enrichment reagents
Provides high quality data
Probes achieve deep and uniform coverage even across GC-rich regions such as first exons
The Exome Panel consists of 429,826 individually synthesized, and quality controlled Swift Probes. The Exome Research Panel spans a 39 Mb target region (19,396 genes) of the human genome and covers 51 Mb of end-to-end tiled probe space. All probes in the panel are manufactured using GMP standards. Mass spectrometry and OD measurements are taken for each probe to ensure appropriate representation of the correctly manufactured probes in the pool.
The Pan-Cancer Panel consists of 7816 Swift Probes, spanning 800 kb of the human genome, for the enrichment of 127 significantly mutated genes implicated across 12 tumor tissue types for deeper sequencing coverage.
The Inherited Diseases Panel enables deeper sequencing of genomic regions containing genes and SNPs associated with inherited diseases. The gene list is based on the HGMD® (Human Gene Mutation Database) repository of known inherited disease-causing mutations.
Detection of germline inherited SNVs and Indels
Low frequency somatic variant detection of SNVs and Indels
Copy number variant detection
Swift 2S Turbo, for high quality genomic DNA and FFPE
Accel-NGS 2S Hyb for FFPE, cfDNA, and incorporation of molecular identifiers (MIDs) for ultra-low frequency variant detection
Accel-NGS 1S Plus for heavily nicked or denatured samples
Ligation-based library preparation kits from other vendors (not compatible with transposon-based kits)
